Research Use Only. Not for human consumption, medical use, diagnosis, or treatment. By purchasing, you agree to laboratory use guidelines.
TESAKLIK 20mg | Tesamorelin Research Pen
TESAKLIK 20mg is a pre-mixed, high-purity synthetic GHRH (1-44) analogue peptide supplied in a precision multi-dose APEX research pen. Formulated with 20mg Tesamorelin in 3ml solution (6.67 mg/ml) — no powder reconstitution or mixing required.
In stock for immediate dispatch — Royal Mail Tracked 24 next-day UK delivery.
TESAKLIK 20mg is a high-purity synthetic Growth Hormone-Releasing Hormone (GHRH 1-44) analogue supplied in a precision multi-dose APEX research pen. Formulated with 20mg pre-mixed Tesamorelin in a 3ml solution (6.67 mg/ml) — requiring no powder reconstitution or mixing. Features an N-terminal modification providing enhanced stability for controlled laboratory and in vitro investigations into GHRH receptor signalling, pituitary cellular communication, and neuroendocrine pathways. Synthesised to ≥99% HPLC purity. Includes 12 disposable needles and instruction leaflet. Strictly for laboratory research and development use only. Not for human consumption, medical use, diagnosis, or treatment.
TESAKLIK 20mg | Pre-Mixed Tesamorelin GHRH (1-44) Analogue Pen
TESAKLIK 20mg is a high-purity synthetic Growth Hormone-Releasing Hormone (GHRH 1-44) analogue supplied in a precision multi-dose APEX research pen. Formulated with 20mg pre-mixed Tesamorelin in a 3ml solution (6.67 mg/ml) — completely eliminating the need for powder reconstitution, manual calculations, or sterile bacteriostatic water mixing.
Compound Profile & Specifications
Chemical RegistryWhat Tesamorelin Is, Chemically
Native human Growth Hormone-Releasing Hormone (GHRH) is a 44-amino-acid peptide released by hypothalamic neurons. In endogenous systems, its first two N-terminal residues are rapidly targeted and cleaved by the ubiquitous enzyme dipeptidyl peptidase-4 (DPP-4), giving native GHRH an in vivo half-life of only several minutes.
Tesamorelin retains the complete, intact 1–44 native sequence and couples a lipophilic trans-3-hexenoyl group to the N-terminal tyrosine. This modification creates steric hindrance that blocks DPP-4 enzymatic cleavage, drastically enhancing compound stability in controlled laboratory and in vitro media while keeping the receptor-recognition region completely unmodified. As a result, Tesamorelin serves as the closest stabilised analogue to native human GHRH available for cellular research.
Tesamorelin vs Other GH-Releasing Peptides
Comparative AnalysisSeveral peptides are studied within growth hormone regulatory pathways, each possessing distinct sequence lengths, structural stabilisations, and receptor targets:
| Compound | Sequence / Structure | Receptor Target | Key Research Characteristic |
|---|---|---|---|
| TESAKLIK 20mg (Tesamorelin) | Full GHRH (1–44), N-terminally stabilised with trans-3-hexenoyl | GHRH Receptor (GHRHR) | Closest full-length analogue to native human GHRH; enhanced enzymatic stability |
| Sermorelin | GHRH (1–29) unmodified fragment | GHRH Receptor (GHRHR) | Shortest fully active native fragment; susceptible to enzymatic degradation |
| CJC-1295 (No DAC) | GHRH (1–29) with 4 amino acid substitutions (Mod GRF 1-29) | GHRH Receptor (GHRHR) | Stabilised 1–29 fragment designed to prolong in vitro receptor interaction |
| Ipamorelin | Pentapeptide secretagogue (Aib-His-D-2-Nal-D-Phe-Lys-NH₂) | Ghrelin Receptor (GHSR-1a) | Selective growth hormone secretagogue acting via ghrelin receptor pathway |
Pre-Mixed Solution vs Lyophilised Powder
TESAKLIK 20mg Pre-Mixed Advantages
- Pre-formulated in sterile 3ml solution (6.67 mg/ml)
- Zero reconstitution calculations or volume errors
- No bacteriostatic water or mixing accessories needed
- Pre-filled into a metered dial multi-dose APEX pen
- Shipped in temperature-controlled insulated packaging
Traditional Lyophilised Powder Issues
- Requires separate bacteriostatic water purchase
- Risk of inaccurate solvent volume measurement
- Potential peptide denaturation from vigorous shaking
- Contamination hazard during manual reconstitution
- Varying batch-to-batch reconstitution concentrations
Primary Laboratory Research Focus Areas
Scientific ResearchIn laboratory endocrinology and cellular biology research, Tesamorelin is evaluated across key investigational pathways:
GHRH Receptor Activation & cAMP Kinetics
Investigated for selective GHRHR binding affinity and subsequent intracellular adenylate cyclase activation and cAMP signalling in somatotroph models.
Hypothalamic-Pituitary Axis Communication
Evaluated in vitro for studying pulsatile neuroendocrine communication and regulatory feedback loops between hypothalamic and anterior pituitary cells.
Lipid Metabolism & Adipocyte Signalling
Studied in adipose cell cultures to assess downstream lipolytic pathway regulation, fatty acid oxidation gene expression, and metabolic homeostasis.
Enzymatic Stability & Peptide Engineering
Used as a benchmark reference standard for measuring N-terminal chemical modification resistance against DPP-4 and neutral endopeptidase cleavage.
Box Contents & Packaging Presentation
Each TESAKLIK 20mg Research Pack Includes:
- 1x Pre-Filled APEX Multi-Dose Pen: 20mg Tesamorelin in 3ml sterile solution (6.67 mg/ml) with adjustable dial mechanism.
- 12x Sterile Disposable Needles: Individually wrapped single-use laboratory research needles.
- 1x Official User Guide: Complete APEX Pharma calibration, storage, and handling instruction leaflet.
- Tamper-Evident Security Seal: Holographic authentication label with unique verification code.
Laboratory Storage & Handling Guidelines
Temperature Control: Store refrigerated between 2°C and 8°C immediately upon delivery. Return to refrigerated storage promptly after laboratory procedures.
Do Not Freeze: Pre-mixed peptide solutions must not be frozen. Freeze-thaw cycles can promote peptide aggregation and compromise tertiary structure.
Light Protection: Store inside the original APEX carton to protect against UV and photo-degradation.
Aseptic Protocol: Adhere to standard laboratory aseptic techniques when handling, sampling, or dispensing solution.
⚠️ Research Compliance Notice
TESAKLIK 20mg is strictly for in-vitro laboratory research and developmental investigations. Not for human or animal consumption, medical use, clinical trials, or therapeutic applications.
Triple Tested
HPLC & MS verified for consistent potency thresholds.
Priority Post
Discreet Next Day Delivery on all research orders.
Official APEX Partner Live Verification
Each research unit features an authentic tamper-evident holographic seal with a unique scratch-to-reveal security code. Enter your code at apexpharma.io/verify to confirm instant product authenticity and view the live Certificate of Analysis for your exact batch.
Frequently Asked Questions — TESAKLIK 20mg (Tesamorelin)
What is TESAKLIK 20mg (Tesamorelin)?
TESAKLIK 20mg is a synthetic peptide analogue of human growth hormone-releasing hormone (GHRH 1-44). Structural modifications (a trans-3-hexenoyl group added to the N-terminal tyrosine) protect it against enzymatic degradation by dipeptidyl peptidase-4 (DPP-4), enabling high stability for controlled laboratory investigations into GHRH receptor signalling. Supplied pre-mixed in a precision 3ml APEX multi-dose research pen strictly for in-vitro laboratory research.
What is Tesamorelin studied for in laboratory research?
In cellular and biochemical research models, Tesamorelin is investigated for binding to and activating GHRH receptors on pituitary-derived cells, triggering cAMP-dependent intracellular signalling cascades associated with endogenous growth hormone regulation. Researchers study its receptor-binding kinetics, transcriptional responses, and hypothalamic-pituitary neuroendocrine pathways.
Do I need to reconstitute TESAKLIK 20mg?
No. Unlike raw lyophilised powders that require sterile bacteriostatic water mixing, TESAKLIK 20mg is supplied pre-mixed in solution in a sealed 3ml APEX multi-dose pen (6.67 mg/ml). There is zero powder to measure, no reconstitution calculation, and no risk of contamination during reconstitution.
What does the TESAKLIK 20mg box contain?
Each TESAKLIK 20mg box contains 1x pre-filled APEX multi-dose metered dial pen (20mg Tesamorelin in 3ml solution), 12x sterile disposable needles, and 1x official user instruction leaflet. Every box includes a tamper-evident hologram with an authentication number.
How does Tesamorelin differ from CJC-1295, Sermorelin and Ipamorelin?
Tesamorelin is the full GHRH (1–44) sequence with an N-terminal trans-3-hexenoyl modification for stability, acting at the GHRH receptor. Sermorelin is the unmodified 1–29 fragment, and CJC-1295 (No DAC) is the 1–29 fragment with four amino-acid substitutions; both also act at the GHRH receptor. In contrast, Ipamorelin is a pentapeptide growth hormone secretagogue acting at the ghrelin receptor (GHSR-1a).
How should TESAKLIK 20mg be stored and handled?
Refrigerate at 2°C–8°C immediately upon arrival. Keep the pen sealed and protected from light. Do not freeze, as freeze-thaw cycles can cause peptide aggregation. Handling must adhere strictly to standard aseptic laboratory protocols.
What purity is TESAKLIK 20mg, and is it lab-tested?
TESAKLIK 20mg is synthesised by APEX Pharma to ≥99% purity verified by High-Performance Liquid Chromatography (HPLC) and mass spectrometry. A batch-specific Certificate of Analysis (CoA) is available on request by emailing your box authentication code.
Is Tesamorelin legal to buy in the UK?
Yes. Tesamorelin is legal to purchase and possess in the UK for laboratory research and development purposes. It is not an approved human or veterinary medicine in the UK and is supplied strictly for in-vitro laboratory research.
Can TESAKLIK 20mg be used for human consumption or treatment?
No. TESAKLIK 20mg is supplied strictly as an in-vitro research chemical for laboratory study. It is not licensed for human or veterinary use, diagnosis, prophylaxis, or medical treatment.